Have been running around Biome 1 to test the malignant items. After 20 or so runs, I feel that the malignancy is very unbalanced. Picking malignant item is harmful most of the time and even the items that you get after cleansing are usually worthless. It never feels like a risk reward mechanics rather a punishing mechanics.
Another thing I noticed was that the game is adaptive. if you do well then you will face tougher enemies and higher number of lockdowns. I played very well in 4-5 of my runs and in those runs every second room (main or side doesn't matter) was a lockdown with overwhelming number of enemies. While in runs where I didn't do well, lockdowns were fewer and even the number of enemies in the lockdowns were not overwhelming. Another interesting observation was that if you pickup astronaut from the fabricator you will certainly face a lockdown in next 2-3 rooms.