The Coronavirus Thread Part 2

[Sapola]

37 minutes ago, hsk_colossus said:

Phase 2 trials .. lolz .. do you know what is assessed in phase 2 trials?

what about us doctors, health care staff, front line workers?? Are they supposed to act as Guinea pigs for the goverment ? 

 

What do you mean guinea pigs?

 

Phase II trial har smaller sample size, 380 people were administered Vaxx. Based on efficacy and other data found here, it was given emergency use approval.

In March, Lancet published P2 data and confirmed the efficiency to be 96%.

 

It's not like they tested on rats and approved for Healthcare workers. ?

[Sapola]

5 minutes ago, Mr. Comingle said:

Dude he's an actual doctor. Are you really gonna argue trial efficacy with him? 

 

What? He is a doctor? Ok lol.

 

But all the points I made, is based on the information which is in public.

 

Govt and not just the Babus or Modi, there was ICMR, Drug Controller of India, which are independent bodies and have competent people, who approved the Covaxib after Phase2, yet one can always have disagreement with their decision.

[hsk_colossus]

3 minutes ago, Right said:

 

What? He is a doctor? Ok lol.

 

But all the points I made, is based on the information which is in public.

 

Govt and not just the Babus or Modi, there was ICMR, Drug Controller of India, which are independent bodies and have competent people, who approved the Covaxib after Phase2, yet one can always have disagreement with their decision.

approval after phase 2? 
Kya dude ...if you don’t know what is actually seen in phase 2 than don’t reply.... 

 

 

 

[Mr_Mediocre]

1 hour ago, Right said:

I know how Civaxin got approval, govt really were lenient, they should’ve waited for phade 3 trial to get over, but they gave in simply for reputation. Bharat biotech is not fly by night operator.

 

Schedule for Covaxin/Covishield is decided ling ago. First 100m doses of Covishield will be subsidised by SII and given to govt and the SII will start putting on open market. SII plans to sell at 1000rs when they it in open market

 

https://www.businesstoday.in/current/corporate/serum-institute-to-supply-covid-19-vaccine-at-rs-250-a-dose-close-to-signing-deal-with-centre/story/424200.html

 

https://www.businesstoday.in/current/corporate/serum-institute-to-supply-covid-19-vaccine-at-rs-250-a-dose-close-to-signing-deal-with-centre/story/424200.html

 

padh likh le bhai tu bhi.

Bhai tu mujhe mat bta kya padhna.

At one side you are advocating how the data of Covaxin was published later on and on the other side you have a problem with Pfizer asking for leniency.

You are quoting old articles after which developments were made. In the end Pfizer agreed to hold trials if they were guaranteed orders in case their efficacy matched or surpassed the one which their US study produced.

How is that problematic? They aren't asking to fund them without producing results like Covaxin did.

Headline padhke degree nhi milti, zara search kro ki hua kya. Ek line padhke dimaag me reh gai and usse hi chipkaye ja rhe ho.

 

Also, SII has already supplied 100M+ vaccines to Govt. and supplied another 30M to Covax alliance, so why is it not putting it on the open market? Why is it not readily available if they had a contract beforehand?

 

Because, they don't have enough Vaccine. They aren't able to fulfill their commitments to AstraZeneca, let alone the free market.

So if they aren't able to do it, then why stop another player?

 

Because then how Govt. will flex its chest post 56 inches.

You absolutely have no knowledge and you don't even try to agree that you might be short on information. This is a kind of absolute power which no force in the universe can beat.

[Mr_Mediocre]

4 minutes ago, Mr. Comingle said:

Adar Poonawala is also playing politics with this. He says he needs INR 3,000 crore to fund capacity increase. That's chump change in the grand scheme of things and he won't have any trouble getting it financed but he wants to blackmail government into giving him grant for it. 

Yeah, I mentioned this earlier.

He says that since Govt. pays SII less than foreign commitments thus he needs the grant.

It's a business at the end of the day.

[hsk_colossus]

COVID-19 Vaccine AstraZeneca: benefits still outweigh the risks despite possible link to rare blood clots with low blood platelets

https://www.ema.europa.eu/en/news/covid-19-vaccine-astrazeneca-benefits-still-outweigh-risks-despite-possible-link-rare-blood-clots

 

[Houndini]

12 hours ago, hsk_colossus said:

 

yet there are election rallies, kumbh mela etc..

do your f**king job, be it Center or state 

 

 

 

Kumbh mela during these times has to be the stupidest dumbest sh*t ever. 

 

11 hours ago, Big Boss said:

Maharashtra government is sh*t but why the f**k is the quack comparing % of vaccinations in Maharashtra with Punjab and Delhi? Dumbass doesn't know the population difference? Shouldn't he look at absolute numbers? Our ministers whether it's state or center are absolutely sh*t. They keep playing politics and want to earn as much as they can while they are in power. Pathetic leadership all around. So many elections happened recently, not a single minister talked about corona. It was full of mudslinging. 

 

You need to look at his earlier comments, both during COVID and pre COVID. He is an idiot. Modi wanted a "doctor" in the cabinet, and he got the worst kind. 

 

10 hours ago, Right said:

Manufacturing is not an issue, they can crank up the production to 10m a day.

Problem is distribution.

 

Eh ? Production ramp up is an issue. SII needs around 3000 crores to ramp up. 

 

10 hours ago, KnackChap said:

A friend of mine who is getting married soon has around tens of lakhs of worth jewellery order placed with 70% paid and is now sh*tting bricks as the store is now closed. Even I got our ordered gold ornaments right on the 5th when the lockdown was supposed to start but was not enforced till late evening or even my money would've been stuck for God knows how long as I'm planning to move out of mumbai. 

 

Mumbai peeps know whom to raid in case sh*t goes south. 

 

10 hours ago, Bhpian Bali said:

 

 

Trials in India are a hogwash.

 

All trials are not hogwash. Let's not make a generalized statement. There is a lot of diplomacy, politics, expert committee discussions etc involved in taking these decisions at the level of CDSCO/DCGI. We see it very closely. 

 

10 hours ago, Right said:

Do you know Pfizer and Moderna have taken sovereign guarantee from the governments including US that there can be no lawsuits if “something goes wrong”. 
Pfizer has asked Latin American countries to put up their buildings and military bases as guarantee to cover legal cost if there are any lawsuits.

 

We are totally covered with Covaxin and covishield, I don’t understand why do we have to go out of way for Pfizer. Give them emergency use approval and then run into issues.

 

Do you think any AEs due to these Covaxin or Covishield are even getting reported ? And please don't be under the impression that you can sue SII or BB. 

Not saying what Pfizer did is right, but with such limited data, there are sh*t ton of things which can go wrong in future. And US has a history of class action lawsuits. 

 

1 hour ago, Right said:

 

What do you mean guinea pigs?

 

Phase II trial har smaller sample size, 380 people were administered Vaxx. Based on efficacy and other data found here, it was given emergency use approval.

In March, Lancet published P2 data and confirmed the efficiency to be 96%.

 

It's not like they tested on rats and approved for Healthcare workers. ?

 

It's a very small sample size for what is essentially a global vaccine. I know it fits the design of P2, but nothing really can be said before a detailed analysis of P3. Thankfully the P3 data is encouraging, but I have read and heard horror stories of how the trial was conducted, mismanaged/unreported AEs etc, so I will take it with a huge dump of salt. 

Edited April 8, 2021 by Bird Bird Bird
Spelling

[Houndini]

12 minutes ago, hsk_colossus said:

COVID-19 Vaccine AstraZeneca: benefits still outweigh the risks despite possible link to rare blood clots with low blood platelets

https://www.ema.europa.eu/en/news/covid-19-vaccine-astrazeneca-benefits-still-outweigh-risks-despite-possible-link-rare-blood-clots

 

 

Ab to chidiya chug gayi khet. >85% vaccination in elderly is with Covishield. And with our already sh*t AE reporting, we won't have any data to analyse. 

 

In other news, who the f**k made it mandatory to get a photo WITHOUT face mask post vaccination at the vaccination centers via Cowin portal ? If someone was not infected, they are surely making them easier to get infected. Vaccine kaam kare na kare, Corona zaroor karega. 

[Mr_Mediocre]

12 minutes ago, Bird Bird Bird said:

Eh ? Production ramp up is an issue. SII needs around 3000 crores to ramp up. 

 

Do you think any AEs due to these Covaxin or Covishield are even getting reported ? And please don't be under the impression that you can sue SII or BB. 

mismanaged/unreported AEs etc, so I will take it with a huge dump of salt. 

Easy there. Otherwise you will be shown news articles and will be told to get your medical degree again.

This is no place for logic and fact checking.

Edited April 8, 2021 by KunjanPSD

[Sapola]

23 minutes ago, Bird Bird Bird said:

Eh ? Production ramp up is an issue. SII needs around 3000 crores to ramp up. 

 

All trials are not hogwash. Let's not make a generalized statement. There is a lot of diplomacy, politics, expert committee discussions etc involved in taking these decisions at the level of CDSCO/DCGI. We see it very closely. 

 

 

Do you think any AEs due to these Covaxin or Covishield are even getting reported ? And please don't be under the impression that you can sue SII or BB. 

Not saying what Pfizer did is right, but with such limited data, there are sh*t ton of things which can go wrong in future. And US has a history of class action lawsuits. 

 

It's a very small sample size for what is essentially a global vaccine. I know it fits the design of P2, but nothing really can be said before a detailed analysis of P3. Thankfully the P3 data is encouraging, but I have read and heard horror stories of how the trial was conducted, mismanaged/unreported AEs etc, so I will take it with a huge dump of salt. 

There is some politics and confusion on this but Covishield alone has current production capability of 70-100m doses per month, which is more than we have vaccinated so far. But they are producing 2M per day, obviously because distribution isn’t sorted.

 

https://m.economictimes.com/industry/healthcare/biotech/healthcare/manufacturing-capacity-of-covishield-70-100-mm-doses-per-month-covaxin-150mm-doses-per-year-dbt/articleshow/81397851.cms

 

 

Secondly, we are having wastage of vaccines,  nearly 6% of doses have been wasted (5L in MH alone!) because vial once opened needs to be used within 4 hrs. 

[Mr_Mediocre]

3 minutes ago, Right said:

There is some politics and confusion on this but Covishield alone has current production capability of 70-100m doses per month, which is more than we have vaccinated so far. But they are producing 2M per day, obviously because distribution isn’t sorted.

 

https://m.economictimes.com/industry/healthcare/biotech/healthcare/manufacturing-capacity-of-covishield-70-100-mm-doses-per-month-covaxin-150mm-doses-per-year-dbt/articleshow/81397851.cms

 

 

Secondly, we are having wastage of vaccines,  nearly 6% of doses have been wasted (5L in MH alone!) because vial once opened needs to be used within 4 hrs. 

They are not ramping up because of the lack of the distribution. That is their theoretical max for which they need funding.

Currently Govt. is burning through 4M+ vaccines a day, even at 70M/month capacity it is not enough.

Also, out of those 70M, India is not getting all of it. SII has legal obligations to fulfill to AstraZeneca and other countries, hence the scarcity.

[hsk_colossus]

14 hours ago, Right said:

If UP or Gujarat had half this case-load, media and opposition would’ve ripped them apart.

https://www.google.co.in/amp/s/www.thehindu.com/news/national/other-states/covid-19-spike-gujarat-hc-suggests-lockdown-for-short-period/article34253883.ece/amp/

Gujarat High Court moots 4-day lockdown amid surging cases and deaths

[Houndini]

10 minutes ago, hsk_colossus said:

https://www.google.co.in/amp/s/www.thehindu.com/news/national/other-states/covid-19-spike-gujarat-hc-suggests-lockdown-for-short-period/article34253883.ece/amp/

Gujarat High Court moots 4-day lockdown amid surging cases and deaths

 

I don't think any lockdowns will happen now. Money + Politics > People. 

[Sapola]

17 minutes ago, KunjanPSD said:

They are not ramping up because of the lack of the distribution. That is their theoretical max for which they need funding.

Currently Govt. is burning through 4M+ vaccines a day, even at 70M/month capacity it is not enough.

Also, out of those 70M, India is not getting all of it. SII has legal obligations to fulfill to AstraZeneca and other countries, hence the scarcity.

A. There is no scarcity, there is a wastage and problem in distribution. Someone with access to real time data mentioned on Twitter that out of 170k odd doses availed to Mumbai, less than 1/3rd were administered. 

 

B. We do not know delivery schedule SII is following, But SII already provided 40m to GOI at the beginning of February. There is no data available  in public which will suggest that vaccine stocks are running out, except political allegation, which debunked by Harshvardhan. He also cited the real time vaccine data. So if someone is serious about the charge of scarcity, they should take screenshots of dashboard and post it.

 

Strangely, this same set of people are asking for opening vaccines for all 18+, If we don’t have scarcity, we will have for sure.

[Sapola]

17 minutes ago, KunjanPSD said:

They are not ramping up because of the lack of the distribution. That is their theoretical max for which they need funding.

Currently Govt. is burning through 4M+ vaccines a day, even at 70M/month capacity it is not enough.

Also, out of those 70M, India is not getting all of it. SII has legal obligations to fulfill to AstraZeneca and other countries, hence the scarcity.

A. There is no scarcity, there is a wastage and problem in distribution. Someone with access to real time data mentioned on Twitter that out of 170k odd doses availed to Mumbai, less than 1/3rd were administered. 

 

B. We do not know delivery schedule SII is following, But SII already provided 40m to GOI at the beginning of February. There is no data available  in public which will suggest that vaccine stocks are running out, except political allegation, which debunked by Harshvardhan. He also cited the real time vaccine data. So if someone is serious about the charge of scarcity, they should take screenshots of dashboard and post it.

 

Strangely, this same set of people are asking for opening vaccines for all 18+, If we don’t have scarcity, we will have for sure.

[radicaldude]

5 minutes ago, Right said:

A. There is no scarcity, there is a wastage and problem in distribution. Someone with access to real time data mentioned on Twitter that out of 170k odd doses availed to Mumbai, less than 1/3rd were administered. 

 

B. We do not know delivery schedule SII is following, But SII already provided 40m to GOI at the beginning of February. There is no data available  in public which will suggest that vaccine stocks are running out, except political allegation, which debunked by Harshvardhan. He also cited the real time vaccine data. So if someone is serious about the charge of scarcity, they should take screenshots of dashboard and post it.

 

Strangely, this same set of people are asking for opening vaccines for all 18+, If we don’t have scarcity, we will have for sure.

 

 

That's why they want other manufacturers to launch their vaccines in india. 

 

 

Ps- govt is actually encouraging monopoly by restricting us to two vaccines only. 

[AtheK]

Yeh bik gai hai gormint

Sent from my HD1911 using Tapatalk

[KnackChap]

No need for personal remarks. Post hidden. 

[Houndini]

12 minutes ago, Right said:

A. There is no scarcity, there is a wastage and problem in distribution. Someone with access to real time data mentioned on Twitter that out of 170k odd doses availed to Mumbai, less than 1/3rd were administered. 

 

B. We do not know delivery schedule SII is following, But SII already provided 40m to GOI at the beginning of February. There is no data available  in public which will suggest that vaccine stocks are running out, except political allegation, which debunked by Harshvardhan. He also cited the real time vaccine data. So if someone is serious about the charge of scarcity, they should take screenshots of dashboard and post it.

 

Strangely, this same set of people are asking for opening vaccines for all 18+, If we don’t have scarcity, we will have for sure.

 

Mate, source of this info ? 

[radicaldude]

https://www.orfonline.org/expert-speak/availability-of-vaccine-supplies-in-india/?amp&__twitter_impression=true