Wow, you must really love this game to have played it so many times... I too completed it with male V & Panam just a day before patch 1.5 was released & absolutely enjoyed every bit of it. I wish it was a bit longer though, specially the last act & also wished it had a new game plus mode. Still it is one hell of an experience. I also wanted to do another playthrough at that time but than decided to wait for a few months when the updated was released. Question is, are the different playthroughs different enough or only minor differences?