The ones you get post eclipse are pretty much useless only..

I switched to a higher-tier rifle midway through Biome 7, but I just couldn’t handle how long it was taking to deplete enemy health bars. It was pumping out a crazy number of rounds, yet all I was really doing was holding R2 and dodging endlessly. I eventually went back and picked up the Reaper, and then cleared Biome 7 without much trouble. Funny thing is, the Reaper was around 12–15 levels lower than the rifle/autogun. For me, the S-tier weapons are definitely the Chakram and the Onslaught. Everything else sits somewhere in A or B tier.

Maybe I'm just bad at using them, getting rekt whenever I use any version of it :/

The artifacts in this game are so useless. For most of my runs, I just ignore them because taking them debuffs your runs so much, rather than helping you.

Anyone who hasn’t tried Chakram weapons….do not sit on them. I have tried 2 - reaper and chainsaw….. both of them annihilate enemies in no time. Reaper is just too good. Clearing nightmares very easily.