Yes some side stuff got story tied to them but none of the side stuff affects main story.
Talk to all your party members multiple times after every big story mission's to increase your relationship with them. Thid will unlock side quests for every character. Go back to camp regularly and exhaust every dialogue options at bonfire and when talking to characters.
Some tell him to play Forbidden West
https://www.videogamer.com/features/former-skyrim-lead-defends-bethesda-loading-screens-necessary-bane/
Ise kehte hai waqt ke saath na badalna aur piche reh jaana. This is the reason starfield bombed. Stuck in 2012 like most MS Studios